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Lipid Peroxide Level in Serum and Aquenous Humor of Diabetic and Non-Diabetic Cataract Patients (Kadar Peroksida Lipid Darah dan Cairan Akueous Penderita Katarak Non-Diabetik dan Katarak Diabetik)

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Cataract is the major cause of blindness in the world. Free radicals are sugested to be involved in cataract formation. The aim of this study was to investigate the possible role of free radicals, measured as lipid peroxide (LP), on cataract formation. LP was estimated by the method of Stringer, measuring the molondialdehyde (MDA) concentration in serum and aqueous humor of diabetic and non-diabetic cataract patients. Serum MDA level pf non-cataract persons was also measured as control. The serum LP levels of the non-diabetic cataract (7.23 plus/minus 2.31 umol/L), diabetic cataract (7.24 plus/minus 1.00 umol/L) and control (6.19 plus/minus 1.91 umol/L) groups were found not to be significantly different (p more than 0.05). The aqueous LP of the non-biabetic cataract (2.54 plus/minus 1.98 umol/l) and diabetic cataract (2.29 plus/minus 1.00 umol/L) patients were also not significantly different (p less than 0.05). No correlation was found between the LP concentration in blood and aquenous humor. Data obtained from this experiment do not indicate any correlation between LP levels and the formation of catarat. Hence, in view of this study, the involvement of LP as a possible factor leading to cataract formation is as yet questioned.

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Majalah Kedokteran Indonesia,46(5)1996:229-232

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: ., 1996

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cataract
peroxides

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