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An Open Pilot Study of The Efficacy and Safety of Polygeline in Adult Subjects With Dengue Haemorrhagic Fever

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To Observe the efficacy and safety of Polygeline colloid (Haemaccel® in adduls with stage 1-11 of dengue hemorrhage fever (DHF). On open, non-comparative clinical trial. The subjects were male or female between 17-55 years old, who fulfilled the criteria of stage 1 or of DHF according to WHO and selected with consecutive sampling. Fluid treatments were given following this protocol polygeline i.v infusion: 500 ml over first 6 hours and continued with 500 ml for the mext 18 hours, and maintained to 1000 mL/24 hours from day-2 until maximum day-5. Ringer’s lactate infusion: 1000 mL/18 hours from the first day to maximum day-5, as maintenance. Efficacy and safety of polygeline colloid were evaluated using initial stabilization of haematocrite level, measured as percentage of clinical trial subject who has stabilization of haemodynamic status based on serial haematocrite levels examination, total porenteral fluid required and length of hospitalization. Statistical analysis was done using ANOVA test and post hoc analysis using Turkey test. There were 43 subjects who completely participated in this study and included in analysis. From baseline levels, haematocrite decrased in first 6 hours during fluid treatment. This decrement persisted in 48 hours of observation. Statistical analysis with ANOVA test showed the significant differences of haematrite level during observation (Sum of square between groups 495 and within group 4845, p=0.000). Post hoc analysis with Turkey test showed significant differences of haematocrite level from baseline level to 48, 72 and 96 hours during observation periods. This pilot study that polygeline colloid was a safe initial fluid treatment and can be use for maintaining fluid adequacy in adults with stage I-III of DHF.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Acta Medica Indonesiana, 41(2): 4753

Penerbit

Jakarta : RS. Cipto Mangunkusumo., 2009

Deskripsi Fisik

5p.

Bahasa

English

ISBN/ISSN

0125-9326

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

DENGUE HEMORRHAGE FEVER
POLYGELINE

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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