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The Role of Incretin on Diabetes Mellitus

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Beta cell dysfunction in type-2 diabetes mellitus holds an important role not its pathogenesis, but also on the progression of the disease. Until now, diabetes treatment cannot restore the reduced function of pancreatic ß cell. Mc Intyre et al stated that there is a factor from the intestine which stimulates insulin secretion as a response on glucose. This factor is known as incretin. It is a hormone which is released by the intestine due to ingested food especially those which contain carbohydrate and fat. Currently, there are 2 types of incretin hormones which have been identified, i.e. Glucose dependent insulinotropic polypeptide (GIP) and Glucagon like peptide-1 (GLP-1). These two hormones act by triggering insulin release immediately after food ingestion, inhibiting glucagon secretion, delaying stomach emptying, and suppressing hunger sensation. Several in vitro studies have demonstrated that these two incretin hormones may increase the proliferation of pancreatin ß cell. There is a decrease of GIP function and GLP-1 amount in type-2 diabetes mellitus: thus the attempt to increase both incretin hormones-in this case using GLP-I against and DPP-IV inhibitor-is one of treatment modalities to control the glucose blood level, either as a monotherapy or a combination therapy. Currently, there are two approaches of in cretin utilization as one of type-2 diabetes mellitus treatment, which is utilization of incetin mimetic/agonist and DPP-IV inhibitor.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Acta Medica Indonesiana, 41(4): 205-212

Penerbit

Jakarta : RS. Cipto Mangunkusumo., 2009

Deskripsi Fisik

8p

Bahasa

English

ISBN/ISSN

0125-9326

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

diabetes mellitus
GASTRIC INHIBITORY POLYPEPTIDE
GLUCOCON-LIKE PEPTIC L

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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