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Reduced Bone Mineral Density and Serum C-Telopeptide Concentration in HIV-infected Patients in Cipto Mangunkusumo Hospital

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To evaluate BDM and bone resorption marker in HIV-infected patients in Cipto Mangunkusumo Hospital, Jakarta. A cross-sectional study was performed between February and May 2008 in adult HIV-infected patients who had not been treated with antiretrovirals. BMD was measured at the lumbar spine by dual energy X-ray obsorptiometry (DEXA) bone densitometer (Lumar Prodigy, GE Medical System, USA), Whereas CTX (C-terminal telopeptide) was measured by an outomated analyzer (Elecsys 2010. Roche Diagnostics GmbH, Mannheim, Germany) using the b-Crosslaps serum reagents. Fourty-two patients were include, comprising 31 (73.8%) men and 11 (26.2%) women. Patients median age was 28 years, ranging from 22 to 39 years old. The peak age group was 26-30 years old Low BMD (osteopenia) was found in 11 (26.2%) of patients. Mean serum CTX level was significantly correlated with BMD (r=0.446: p+0.003). Patients with low CD4 count and low BMI tended to have higher serum CTX. HIV-infected, treatment-naïve patients possess a significant risk for reduced BMD due to increase bone resorption activity. Faurther studies are needed to evaluate the association of disease sverity and bone resorption markers.

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Detail Information

Series Title

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Call Number

Acta Medica Indonesiana, 41(4): 191-194

Publisher

Jakarta : RS. Cipto Mangunkusumo., 2009

Collation

4p.

Language

English

ISBN/ISSN

0125-9326

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

HIV
BONE DENSITY

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