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Molecular Mechanism on Healing Process of Peptic Ulcer

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Ulcer healing process is an intricate and active process including reconstruction process of mucosa through formation of granulation tissue. Granulation tissue formation takes place by means of formation of ulcer base, formation of blood vessel (angiogenesis) and re-establishment of glandular architecture. The process of granulation tissue formation on the ulcer base takes place 48-72 hours after ulceration process occurs. These there phases involve various genes grouped according to their activated time, i.e. the initial response genes, intermediate response gene and late response genes. Intial response genes are activated in 30 minutes to 2 hours time,e.g EGF-R c-fos, c-jun, egr-1, Sp-1. TFF-2/SP. Intermediate response ganes are activated for 6 hours to 2 days, eg EGF, bFGF, PDGF and VEGF. Late response genes are activated for 14 days, e.g. HGF, ITFC-met/HGF-R.

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Detail Information

Series Title

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Call Number

Acta Medica Indonesiana, 41(2): 95-98

Publisher

Jakarta : RS. Cipto Mangunkusumo., 2009

Collation

4p.

Language

English

ISBN/ISSN

0125-9326

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

peptic ulcer

Specific Detail Info

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Statement of Responsibility

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