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Seizure Threshold, Hormones and Anti-Epileptic Drugs

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The concept of seizure threshold holds that everyone has a certain balance between excitatory and inhibitory forces in brain. A low seizure threshold makes it easies for epilepsy to develop and easier for someone to elicit singl sezure. The opposing effects of estrogen (proconvulsant) and progesterone (anticonvulsant) on seizure threshold have been noted in animal and human studies. Eastrogen has been shown to lower the seizure threshold. In contrast to estrogen, several studies have confirmed the anticonvulsive effects of progesterone and its mecablite. Anti-epileptic drugs (AEDs) are used to prevent or interrupt seizures. Limitation of sustained repetive neuronal firing via blockade of voltage-dependent sodium channels, enhancement of GABA-mediated inhibition, and blockade of glutamatergic excitatory neurotransmission are the mechanisms of anti-epileptic drugs in preventing seizures. AEDs that induce heduce hepatic cytochrome (CY) P450 enzures can increase the metabolism of sex hormones and make hormonal contraception inffective. In addition, AEDs may even increase seizure frequency or severity or change the seizure type.

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Detail Information

Series Title

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Call Number

Universa Medicina, 27(1): 18-28

Publisher

Jakarta : Trisakti Universiti Press., 2008

Collation

11p.

Language

ISBN/ISSN

1907-3062

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

anticonvulsants
hormones
SEIZURES

Specific Detail Info

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