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Efek Pemberian Ubiquinon pada Penyakit Paru Obstruktif Kronic Stabil

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Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation that is not fully reversible. An importance factor in exercise limitation is ventilator is ventilator disturbance because of airflow limitation and increase work of breathing in the diaphragm. Respiratory muscle dysfunction contribute to dyspnoea and the onset of hypercapnea. This reduction in peripheral and respiratory muscle function contributes to reduce exercise tolerance. Ubiquinone is contained in mitochondria and has an important role in aerobic energy production and metabolism. Administration of ubiquinone could improve the quality of life of patient with stable chronic obstructive pulmonary disease. A controlled clinical trial was performed with randomized and double-blind. Patient were eligible if they were stable COPD as GOLD criteria, ages more than 30 years old. Patient were randomly assigned to receive ubiquinone or a placebo for 12 weeks. Patient were instructed to cntinue other routine medication. All patient was assessed the level of lactate, lung funcition, blood gas analysis, six minute walking test and quality of life patient of COPD with St George’s Respiratory Questionnare (SGRQ) before and after 12 weeks ubiquinone or placebo administration. A total 60 patients were available for outocome analysis, 30 patients in an ubiquinone group and 30. Patient in controlled group. There were no differences between the two patient group with regard with to gender, stage of COPD, BMI. The serum level of lactate was significantly decrease in an ubiquinone group compare controlled group (1.10+1.1, -1.02+0.94; p0.05). There were significantly an increase in distant of six minute walking test in ubiquinone group compare controlled group (-35.78±27.30, 0.21 ±25.90: p< 0.01). Patient who had received ubiquinone showed significantly improvement of SGRQ score in symptoms, acivity and impact compare to placebo (22.32 ±9.10 vs -1.42+3.68, p

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Detail Information

Series Title

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Call Number

Jurnal Respirologi Indonesia, 28(4):206-218

Publisher

Jakarta : Perhimpunan Dokter Paru Indonesia., 2008

Collation

13p.

Language

ISBN/ISSN

0853-7704

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Edition

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Subject(s)

quality of life
PULMONARY DISEASE,CHRONIC OBSTRUCTIVE
UBIQUINONE

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