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Perbandingan Hasil kahir Pengobatan Obat Antituberkulosis Kombinasi Dosis Tetap (KDT) dengan Kombipak pada Pengobatan Tuberkulosis Paru dengan Strategi DOTS di Puskesmas Kecamatan Jatinegara, Pulogadung dan Mataram Jakarta Timur

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Combipack, anti-tuberculosis drug which is used in (Indonesia’S National Tuberculosis to treatment and many factors. Effective treatment of tuberculosis patient with short- Programme has been available since 1993. This formulation has high effectivity in tuberculosis treatment, likewise cure rate result still lower. It was influence by patient do not adhere course multidrug chemotherapy is the cornerstone of the modern aproach to the control the disease. To emphasize this principle, WHO and the International Union Againts Tuberculosis and Lung Disease (IUATLD), together with their partners, recommend their partners, recommend the use of the fixed-dose combination (FDC) formulation of the essential anti-tuberculosis drugs as one further step to ensure adequate treatment of patients. In 1999 Indonesia had been used FDC in prelimminary studied in health centres in the South Sulawesi Province wih excellent result for the Combipack and the FDC regimens. In Jatinegara, Mataram and Pulogadung Community Health Centres, East Jakarta, DKI Jakarta province, never use the FDC. So we study to compare the end result of ant-tuberculosis drugs FDC with Cimbipack on treatment the pumonary tuberculosis with DOTS strategy. A prospective, open randomized negative clinical trial is performed to compare the end result of anti-tuberculosis drugs FDC with combipack on treatment the pulmonary tuberculaosis with DOTS strategy. The samplng procedure was consecutive sampling. Samples were patients with new smear-positive pulmonary tuberculosis, informed concent and standard recording and reporting. Patient fulfilling the inclusion are randomly alocated to either the Combipack or FDC regimen. For each of the drugs needed in the treatment of tuberculosis, there are a well defined recommended dose per kg body weight. There were 94 patient (47 treated with combipack and 47 treated with FDC). During the treatment, there were 1 patient completed thetapy, 1 patient default, 1 patient death on the combipack regimens and 1 patient completed, 1 transfer out, 1 patient failure therapy on the FDC regimens. The Combipack regimens results, conversion rate was 91,5%, success rate was 95,7%, cure rate was 95,7%, cure rate was 95,7% and the FDC regiment results, conversion rate was 97,9%. Succes rate was 95,7%, cure rate was 95,7%. Interestingly no significant different results with the both. The FDC regiments have similar efficacy at finakl treatment of the end result with the Combipack regimens in the management of pulmonary tuberculosis.

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Detail Information

Series Title

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Call Number

Jurnal Respirologi Indonesia, 28(3): 145-154

Publisher

Jakarta : Perhimpunan Dokter Paru Indonesia., 2008

Collation

10p.

Language

ISBN/ISSN

0853-7704

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Media Type

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Carrier Type

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Edition

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Subject(s)

tuberculosis, pulmonary
ANTITUBERCULOSIS AGENTS

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