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Pola dan Sensitiviti Koman PPOK Eksaserbasi Akut yang Mendapat Pengobatan Echinacea Purpurea dan Antibiotik Siproflokeasin
Exacerbation, mostly of an infectious etiology, are frequent cause of morbidity and mortality in COPD patient. The rle o bacterial patern in sputum of patients wirh acute bacterial exacerbations of COPD, the possible relation between functional respiratory impairment (measured by FEV1) and isolation of diverse pahogens in the sputum and to determine the role of Echinacea purpurea in bacterilogical response at the end of treatment with ciprofloxacin. This design study is cross-sectional and randomized double blind controlled with placebo. Subjects were devided in three randomized group and given Echinacea purpurea + vitamin C, Zn and Se (EP) or pure Echinacea purpurea (PEP) or placebo (PL) ceplet once daily for 14 days. Cprofloxacin was given for 7 days. A quantitative sputum culture was performed from one hundred and twenty specimens from patients with acute bacterial exacerbation of COPD and bacterial grwoth was considered significant only when the germ was isolated at concentrations > 10 pangkat 6 CFU/mL (> 10 pangket 5 for Streptococcus pneumoniae) in samples accepted wih Barlett’s grading score criteria. Sixty four germs significant quantitative cultures isolated from sputum were the followin: S pyogenes (24 cass; 37,5%), Spneumoniae (12 cases; 18,75%), Sß-haemolyticus (10 cases; 15,63%), P aeruginosa (9 cases; 14,06%), Klebsiele pneumoniae (5 cases; 7,81%), Acinobacter baumanii (4 cases; 6,25%) P aergunosa and FEV1 > 50% (p
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