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Effek vasodilatasi kurkumin dan turunannya pada organ aorta tikus terisolasi (The vasodilation effects of curcumin and its derivatives on isolated aortic of rats

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Hypertension is a disease which need a complex therapy and high cost of drugs. This fact urge exploration of new antihypertensive drug. The aim of the research was to asses to look at the activity of curcumin and its derivatives bisdemethoxy curcumin and bis (demethoxydehydroxy) curcumin on the contraction of isolated organ smooth muscle induced by an ά1 – on the adrenergic receptor agonist (phenylephrine) and to assay relaxation effect research was conducted using an isolated organ technique with isotonic transducer.
The results have shown that curcumin and its analogs bisdemethoxy curcumin and bis (demethoxydehydroxy) curcumin could inhibit the contraction of isolated organ smooth muscle, and showed relaxation effects of this organ. The inhibitory effect on the isolated organ might be mediated by non-competitive antagonism mechanism on ά1 –adrenergic receptor, whereas the relaxation effects were suggested through nitric oxide (NO) independent pathway.

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Detail Information

Series Title

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Call Number

Majalah Farmasi Indonesia: Vol. 19 (2) 2008: 70-77

Publisher

Yogyakarta : Fakultas Farmasi UGM, Badan Litbangkes., 2008

Collation

8 p.

Language

ISBN/ISSN

0126-1037

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

VASODIATION
CURCUMIN.
RATS.

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