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Ekspresi Vascular Endothel Growth Factor-B (VEGF-B) pada Adenokarsinoma (Vascular Endothel Growth Factor-B (VEGF-B) Expression in Colorectal Adenocarcinoma)

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Colorectal adenocarcinoma is the glandular malignancy of colorectal epithelial layer. Angiogenesis process is needed for growth and metastasized of the adenocarcinoma and Vascular endothelial growth factor-B (VEGF-B) is one of the important factor in the angiogenesis process. This study was conducted to determine the correlation of vascular endothelial growth factor-B (VEGF-B) expression in colorectal adenocarcinoma with tumor grade, Duke's stadium, age, sex, and primary location of the malignancy. This retrospective study collected 30 samples of colorectal adenocarcinoma and stained with immunohistochemistry method used VEGF-B (Santa Cruz Biotechnology, Inc). The age of the patient's were 19-80 years-old, 17 were women and 13 were men. Mean age was 47 years old. The grade of colorectal adenocarcinoma were well differentiated in 20 cases, moderately differentiated in 4 cases, and six cases were poorly differentiated. None of the cases was Duke's A, 17 cases were Duke's B, twelve cases were Duke's C, and only one case was Duke's D. Mostly, the primary location of the malignancy were in rectosigmoid (17 cases). The expression of the V~GF-B was in the cytoplasm and the intensity range was +1 (weak), +2 (moderate) and +3 (strong). Well differentiated adenocarcinoma with strong expression of VEGF-B were detected in five cases (25%), moderate expression were 13 cases (65%), and weakly expression were 2 cases (10%). Moderately differentiated adenocarcinoma with VEGF-B strong expression were in 3 cases (75%), and moderate expression was one case (25%). Poorly differentiated adenocarcinoma with strong expression of VEGF-B were found in all six cases (100%). The conclusion revealed that the intensity of VEGF-B immunoexpression is higher in poorly differentiated adenocarcinoma colorectal than others grade, but do not correlate with age, sex, primary location of malignancy, and Duke's stadium of the tumor. The result of this study hopefully could encourage anti-angiogenic therapy in such tumor

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Detail Information

Series Title

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Call Number

Majalah Kedokteran Bandung, 40(2)53-58

Publisher

Bandung : Fakultas Kedokteran Universitas Padjadjaran., 2008

Collation

3p.

Language

ISBN/ISSN

0126-074X

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

colorectal neoplasms
ADENOCARSINOMA
VASCULAR ENDOTHELIAL
GROWTH FATOR B

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