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Sensitivity Pattern of Corneal Ulcer Bacteria against 12 Antibiotics (Pola Kepekaan Kuman Penyebab Ulkus Kornea terhadap 12 Macam Antibiotika)

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Corneal ulcers is one of the difficult case to handle, most of them causes a blindness. It needs an antibiogram in order to choose drug of choice, however, it takes time. So sensitivity patterns is important as guidance to choose an initial antibiotic treatment to the patient. Sensitivity test of 42 isolates from 33 corneal ulcer patients against 12 antibiotics have been done, using disc diffusion methods. The microbes isolated are staphylococcus epidemidis (42.8 percent), pseudomonas aeruginosa (21.4 percent), alcaligenes fecalis (24.4 percent), enterobacter (9.5 percent) and staphylococcus aureus (4.9 percent). Resistance rate of almost all bacteria more than 50 percent was found against chloramphenicol, tetracyclin, polymixin-B, neomycin and bacitracin. While against gentamycin, dibekacin, tobramycin and ciprofloxacin, around 70 percent or more were still sensitive. Erythromycin and augmentin (amoxycillin) are sensitive enough against gram (+) bacteria only, and about half of co-trimoxazole was resistant to all bacteria isolated. Most of the bacterias were sensitive to ciprofloxacin. It is concluded that the most prevalent of causative bacteria in corneal ulcer bacteria are staphylococcus epidermidis, pseudomonas aeruginosa and alcaligenes fecalis. They were resistant to widely used antibiotics, but highly sensitive to relatively new antibiotics. Multidrug resistant bacterias were encountered in more than 75 percent of all isolated bacteria.

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Majalah Kedokteran Diponegoro,31(3 4)1996:177-184

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: ., 1996

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antibiotics
corneal ulcer

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