Identification of Cystathionine Beta Synthase (CBS) and Methylenetetrahydrofolate Reductase (MTHFR) Genes Mutations in Premature Myocard Infarct Acute Patients with Hiperhomocystenemia | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Identification of Cystathionine Beta Synthase (CBS) and Methylenetetrahydrofolate Reductase (MTHFR) Genes Mutations in Premature Myocard Infarct Acute Patients with Hiperhomocystenemia

I Ketut Gede muliartha - Personal Name; Djanggan Sargowo - Personal Name; Abdilah Iskandar - Personal Name;

Hyperhomocysteinemia appears to be an independent risk factor for coronary heart disease Elevated levels of plasma total homocysteine (tHcy) was caused by genetic or nutrient-related disturbances in the transsulfuration or remethylation pathways for homocysteine metabolism. This study observed premature yocard infarct acute patients with hyperhomocysteinemia. The aim of the research was to determine Cystarhionine-ß tients with hyperhomocysteinemia. This study was a cross sectional study in premature acute myocard infarct patients. Twenty three patients were examined for plasma total homocysteine, vitamin B6, vitamin B12 folic acid and lipid profile. Total DNA isolated from patients with hyperthomocystememia and normal folic acid, vitamin B6, vitamin B12 levels and lipid profile. Five patients were assayed for Cystathionine-ß Synthase and gen Methylenetetrahydrofolate Reductase genese mutations by Polymerase Chain Reactions (PCR). Five from 23 patients (21,7%) plasma total homocysteine were increased (15,10 ± 2.02 nmol/L) with normal vitamin B6 (35.06 ± 11,80 nmol), vitamin B12 (A67,60 ± 207, 18 pg/ml), folic acid (8,28 ± 2,26 ng/ml) levels and lipid profile (180 ± 9,80 mg/dl). After visualitation of PCR product, there were mutations in Cystathionine-ß Synthase and gen Methylenetetrahydrofolare Reducrase genes. It was concluded that Cystathionine-ß Synthase and gen Methyleneterrahydrofolate Reductase genese mutations occurs in Premature Acute Myocard Infarct patients with hyperhomocysteinemia.

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Location name is not set Jurnal Kedokteran Brawijaya,24(3):111--119

A0000290

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Series Title: -
Call Number: Jurnal Kedokteran Brawijaya,24(3):111--119
Publisher: Malang : Fk. Universitas Brawijaya., 2008
Collation: 5P.
Language
ISBN/ISSN: 0216-9347
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Edition: -
Subject(s): myocardial infarction
HYPERHOMOCYS TEINNEMIA
CYSTATHIONINE BETA-SYNTHASE
METHYLENETETRA-HYDROFOLATE REDUCTASE
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