Identification of Cystathionine Beta Synthase (CBS) and Methylenetetrahydrofolate Reductase (MTHFR) Genes Mutations in Premature Myocard Infarct Acute Patients with Hiperhomocystenemia | Perpustakaan dan Galeri Kebijakan Kesehatan

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Identification of Cystathionine Beta Synthase (CBS) and Methylenetetrahydrofolate Reductase (MTHFR) Genes Mutations in Premature Myocard Infarct Acute Patients with Hiperhomocystenemia

I Ketut Gede muliartha - Nama Orang; Djanggan Sargowo - Nama Orang; Abdilah Iskandar - Nama Orang;

Hyperhomocysteinemia appears to be an independent risk factor for coronary heart disease Elevated levels of plasma total homocysteine (tHcy) was caused by genetic or nutrient-related disturbances in the transsulfuration or remethylation pathways for homocysteine metabolism. This study observed premature yocard infarct acute patients with hyperhomocysteinemia. The aim of the research was to determine Cystarhionine-ß tients with hyperhomocysteinemia. This study was a cross sectional study in premature acute myocard infarct patients. Twenty three patients were examined for plasma total homocysteine, vitamin B6, vitamin B12 folic acid and lipid profile. Total DNA isolated from patients with hyperthomocystememia and normal folic acid, vitamin B6, vitamin B12 levels and lipid profile. Five patients were assayed for Cystathionine-ß Synthase and gen Methylenetetrahydrofolate Reductase genese mutations by Polymerase Chain Reactions (PCR). Five from 23 patients (21,7%) plasma total homocysteine were increased (15,10 ± 2.02 nmol/L) with normal vitamin B6 (35.06 ± 11,80 nmol), vitamin B12 (A67,60 ± 207, 18 pg/ml), folic acid (8,28 ± 2,26 ng/ml) levels and lipid profile (180 ± 9,80 mg/dl). After visualitation of PCR product, there were mutations in Cystathionine-ß Synthase and gen Methylenetetrahydrofolare Reducrase genes. It was concluded that Cystathionine-ß Synthase and gen Methyleneterrahydrofolate Reductase genese mutations occurs in Premature Acute Myocard Infarct patients with hyperhomocysteinemia.

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Belum memasukkan lokasi Jurnal Kedokteran Brawijaya,24(3):111--119

A0000290

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Judul Seri: -
No. Panggil: Jurnal Kedokteran Brawijaya,24(3):111--119
Penerbit: Malang : Fk. Universitas Brawijaya., 2008
Deskripsi Fisik: 5P.
Bahasa
ISBN/ISSN: 0216-9347
Klasifikasi: -
Tipe Isi: -
Tipe Media: -
Tipe Pembawa: -
Edisi: -
Subjek: myocardial infarction
HYPERHOMOCYS TEINNEMIA
CYSTATHIONINE BETA-SYNTHASE
METHYLENETETRA-HYDROFOLATE REDUCTASE
Info Detail Spesifik: -
Pernyataan Tanggungjawab: -

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