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Study on the Fine Neddle Aspiration Biopsy Compared with Frozen Section at Anatomy Pathological Ward Dr. Kariadi Hospital (Studi Banding Pemeriksaan Sitologi Biopsi Aspirasi Jarum Halus dengan Potong Beku di Bagian Patologi Anatomik FK Undip/RSUP Dr. Kariadi)

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Fine Needle Aspiration Biopsy (FNAB) is a relatively new diagnostic technique in cytology. FNAB is done using a thin needle (usually 22-25 gauge) introduced directly into the target tissue, and the sample is processed as cytological smear. The diagnostic accuracy of FNAB is varied, depend on many factors e.g. precision in tissue sampling and on the expert of the pathologist. The objective of this study is to gain experiences in FNAB and to assess its diagnostic occuracy compared with frozen section diagnosis. The gold standard is histopathological diagnosis. During a three months period (June-August 1993), aspiration biopsies were done to all surgical specimens referred to the Department to Pathology for frozen section using 23 gauge needles directly to the tissues. The samples were air-dried and stained using May-Gruenwald Giemsa method. Frozen section diagnosis and histological examinations were also done for comparisons. Twenty surgical specimens were received for frozen section examination during that period, consisting of 7 mammary glands (35 percent), 6 thyroid (30 percent), 4 ovaries (20 percent) and 3 other cases (19 percent). The accuracy of FNAB was 85 percent, with sensitivity 66.6 percent and specificity 92.8 percent. Whereas, the accuracy of frozen section diagnosis was 95 percent, with sensitivity 92.8 percent and specificity 100 percent. There is a false positive FNAB diagnosis for mammary lesion, and two false negative for skin and thyroid malignancies. Although the accuracy of FNAB is lower than frozen section diagnosis. this technique is usefull as a supplementary diagnosis of frozen section.

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Majalah Kedokteran Diponegoro,31(3 4)1996:141-147

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: ., 1996

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biopsy, needle
frozen sections

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