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Interaksi Obat dan Beberapa Implikasinya

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Drug-drug interactions can initiate undesirable or adverse effects. This could have a clinical
implication and could also become serious health problems. Since a large number of drugs are
introduced and marketed every year, new interactions between concomitant medications might possibly
increase. The safety profile of drugs including the impacts of drug-drug interactions can be provided
from pharmacoepidemiology and pharmacovigilonce data. There are some mechanisms of drug-dug interactions, i.e. pharmaceutics interaction, pharmacokinetics and pharmacodynamics interactions. However, only harmacodynamic interaction can be predicted and the effect usually applies equally to any drugs in the same class therapy. On the other hand, pharmacokinetic interactions cannot be predicted or extrapolated to any drugs in the same class
therapy because of differences in their pharmacokinetics profiles. Information on how is the mechanism
of drug-drug interaction is needed, so the possible adverse effect due to drug-drug interactions can be
anticipated.
Keywords: drug-drug interaction, adverse effect, pharmacokinetics, pharmacodynamics

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Ketersediaan

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Informasi Detail

Judul Seri

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No. Panggil

Media Litbang Kesehatan,18(4):175-184

Penerbit

Jakarta : Badan Litbang Kesehatan., 2008

Deskripsi Fisik

5P.

Bahasa

ISBN/ISSN

1410-2935

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

PHARMACOKINETICS
DRUG INTERACTION
ADVERSE EFFECTS

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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