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Isolasi dan Identifikasi senyawa Kumarin dari Tanaman Artemisia Annua (L)

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The invention of new entity from plant was the basic step for chemistry and another sciences
development, such as: pharmacy, biology, and medical. Besides that, it is needed to fulfill people needs
on food, medicine, cosmetics, etc. Coumarine is fenilpropanoid that has biological activity to stimulate
skin pigmentation, influence enzyme activity, anti coagulant, anti microbial and inhibition of
carcinogenic effect. One of the plants that contain coumarine is Artemisia annua L, because of that we
interested in isolating coumarine and it's derivate in Artemisia annua L with expectation that study
resulted in discovering anti cancer agent. The method that we use is extraction and soxhletation using
methanol and fractionation using dichloromethane. The separation was done by column
Chromatography with silica gel and eluent n-hexane:etil acetate. Purification was done by
re crystalization. Isolate is identified using KLT. GC-MS, Spectrophotometer UV/, IR and NMR. This
study shows that isolate was coumarine named 2H-1-Benzopyran-2-one, 7-hydroxy-6-methoxy or
Scopoletin with molecular weight 192
Keywords: Coumarine, Artemisia annua L, TLC, FTIR, GC-MS, NMR

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Detail Information

Series Title

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Call Number

Media Litbang Kesehatan,18(3):107-118

Publisher

Jakarta : Badan Litbang Kesehatan., 2008

Collation

6p.

Language

ISBN/ISSN

1410-2935

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

plants, medicinal
CAUMARINS

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