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Dengue IgG/IgM Antibodi Rapid Test (IR-113c) sebagai Perangkat Diagnostik Cepat Demam Berdarah Dengue

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Dengue Haemorraghic Fever (DBD) remains one of the main major health problem, The morbidity
rate increases from year to year, especially in the urban area like Jakarta. It is caused by flaviviridae
virus, and transmitted through mosquitoes biting (Aedes aegypti or Aedes albopictus). Although the
morbidity from 1990 to 2006 was high (total cases showed 22.807 in 1990, and 111.730 in 2006), the
case fatality rate (CFR) were gradually decrease (CFR showed 3,60% in 1990 and 1,41% in 2006). The
problem is in the early clinical manifestation of dengue virus infection causes a broad spectrum of
illnesses, may as an asymptomatic infection, a like undifferentiated fever, a common influenza, a
chikungunya, or as a typhoid fever. Prompt and accurate diagnosis is needed, to saving the lives of
DBD patients. In order to get prompt and accurate diagnosis for dengue virus infection, we validated a
Dengue IgG/IgM Antibody Rapid TestIlR-113c) (produced by Oncoprobe), using 61 sera taken from
dengue infected patients from Jakarta, Semarang and Medan. All sera were paired or taken from acute
and convalescence phases of infection. RDT result were compare to HI (Haemaglutination Inhibition)
Test as a gold standard, ELlSA test was also be done to measure the titers of IgM and IgG. It was found
that this device showed 76,9% (76,8-77) sensitivity (Se), 77,7% (77,6-77,8) specivicity (Sp), 77,05%
(76,95-77,15) accuracy, 95,2% (95,45-95,25) and 36,8% (36,68-36,92) positive predictive value (ppv)
and negative predictive value (npv), all those result were statistically valid (X1= 10,7, P = 0,001), The
convalescence sera showed 98,1% (98,07-98,13) sensitivity (Se), 77,7% (77,6-77,8) specivicity (sp),
95,1% (95,05-95,15) accuracy, 96,2% (96,16-96,24) and 87,5% (87,42-87,58) positive predictive value
(ppv) and negative predictive value (npv), all those result were statistically valid (X2 = 38,74, P =
0,000). Dengue IgG/IgM Antibody Rapid Test/IR-1l3c has an adequate sensitivity and accuracy
however it is less specific. This device showed higher validity for convalence sera.

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Detail Information

Series Title

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Call Number

Media Litbang Kesehatan

Publisher

Jakarta : Badan Litbang Kesehatan., 2008

Collation

4p.

Language

ISBN/ISSN

0853-9987

Classification

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Media Type

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Edition

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Subject(s)

DENGUE HEMORRHAGIC PEVER
ENZYME-LINKED IMMUNOSOR BENT ASSAY

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