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he Combination Effect of Artemisinin and N-acety;custeine (NAC) on the Level of Cerebral and Lung Molonialdehyde (MDA)of Balb/c Mice Infected wWith Plasmodium berghei

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Cerebral and lung during malaria infection is believed to be caused by free radicals activities that are produced during immunology process. The free radicals reacts with lipid component of cellular membrane which generates malondialdehyde (MDA) at its end-product. The aim of the research was to determine whether combination of artemisinin and NAC was more effective in decreaseing cerebral and lung MDA level compared to artemisinin mono-therapy. The research was post-test-control-only design using 5 groups consisted of group A (negative control group), group B mice which infected with P. berghei without therapy (positive control group), group C mice which infected with P.berghei and received artemisnin mono-therapy (0.04 mg/ BW for 7 days), group D mice infected with P.berghei and received artemisinin in combination with NAC (1 mg/g BW for day 7 days) and group E mice which infected with P.berghei received artemisinin in combination with NAC (1 mg/g BW for 3 days and tapered in to ½ mg/g BW for 4 days). On the 3 rd, 5th, and 7th day, 3 mice from each group wee scarified and assayed for MA level. On the 3 rd, a decreasing trend of cerebral and lung MDA level was observed on all treatment groups. On the 5th day, a decreasing trend of cerebral and lung MDA level was observed in group that received artemisinin and NAC whereas group’s that received artemisinin mono-therapy increased. Cerebral and lung MDA level of group that received artemisinin mono-therapy was significantly different with group that received combination of artemisinin and NAC in constant dose (p=0.014) and with group that received combination artemisinin and NAC in tapering dose (p=0.004). One the 7th day, cerebral MDA level ofgroup that received combination artemisinin and NAC in constant dose was significantly lower than the group that received artemisinin mono-therapy (p=0.005). In the lung, the MDA level of group that received artemisin mono-therapy increased, while the MDA level combination group decreased. There was a significantly difference between group that receiving artemisinin mono-therapy and group that received combination of artemisinin and NAC tapering dose (p=0.000). The conclusion is the combination of artemisinin and NAC is more effective in lowering cerebral and lung MDA level compared to artemisinin mono therapy on mice infected with P.berghei

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Series Title

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Call Number

Jurnal Kedokteran Brawijaya, 24(2): 73-78

Publisher

Malang : Fk. Universitas Brawijaya., 2008

Collation

3p.

Language

ISBN/ISSN

0216-9347

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Edition

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Subject(s)

malaria
brain
lung
malondialdehyde
ARTEMISININS

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