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The Role of Leptin Toward the Activity of Maturation-Promoting Factor (MPF) at Oocyte Maturation

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Oocyte maturation is mediated by active Maturation Promoting Factor (MPF)in ooplasma. Maturation Promoting Factor (MPF) is heterodimer protein consists of sub catalytic unitp34cdc2 and sub regulator unit of cyclin-B . The regulation of maturation promoting factor (MPF) occurs throught phosphorylation and dephosphorilation Cdc2 while its acitivities are controlled by the accumulation and periodical degradation from Cyclin-B during cell cycles development. Leptin in known has role on oocyte maturation that works at mitogen activated protein kinase (MAPK). MAPK belongs to protein kinase family Ser/Thr that interact with MPF in arranging the proresivennas of oocyte meiosis through the help of c-mos. This interactions initiated phosphorilation of Ser-369 and Thr-577 in p90rsk.

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Series Title

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Call Number

Jurnal Kedokteran Brawijaya, 24(1): 36-43

Publisher

Surabaya : Puslitbang Farmasi, Badan Litbang Kesehatan., 2008

Collation

5P.

Language

ISBN/ISSN

0216-9347

Classification

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Content Type

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Media Type

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Edition

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Subject(s)

MATURATION-PROMOTING FACTOR
LEPTIN
OOCYTES

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