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The Effectiveness of Rectal and Oral Paracetamol in Decreasing Fever in Children

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Background: The common treatment to reduce fever is administration of paracetamol orally, However, oral acute is sometimes not possible due to some problems, such as vomiting, irritability, unconsciousness, and convulsion and therefore, paracetamol in febrile children. Methods: This study wa a parallel randomized, double-blind, controlled trial, comparing the effectiveness of rectal paracetamol to oral paracetamol. The study subjects were children with fever. Consecutive sampling was used to collect samples, and block randomization was used for random allocation. The study was conducted from November 1, 2006 to April 30, 2008. The body temperature was measured just before taking the drug (t0), and was monitored after 30 minutes (t1), 60 minutes (t2), 90 minutes (t3), 120 minutes (t4), 150 minutes (t5), and 180 minutes (t6). Inferential statistic tests used wre chi square, t-test and Mann Whitney U test. Results: A total of 176 subjects eligible for the study were randomly assigned to receive either paracetamol 12,5 mg/kgBW orally (88 subjects). There were 6 subjects who were drop-out and 1 subject failed from rectal group, and 6 subjects were drop-out and 2 subjects failed from oral group, paracetamol average dose for each group was 12.5 mg/kgBW. The proportion of the decrease in body temperature to 38ºC in the first 30minutes was significantly higher ??? in oral group. The change in body temperature from initial body temperature between oral and rectal routes after 30 minutes was significantly different (t0-i1:p=0.003), but later decrease was not statistically different (t0-t2:p=0.471, to=t3: p=0.488, t0-t4: p=0.824, t0-t5: p=0.790, t0-t6: p=0.493); the differences between two periods of measurement were not significant (t1-t2:p=0.073, t2-t3: P=0.791, t3-t4:p=0.171, t4-t5: p=0.199, t5-t6: p=0.426), except from t0-t1 (p=0.005). Conclusion: Rectal paracetamol 12.5 mg/kgBW had a higher effectiveness compared with oral paracetamol to reuce fever in children.

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Series Title

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Call Number

Berkala Ilmu Kedokteran, 40(4): 208-214

Publisher

Surabaya : Fk. Universitas Gajah Mada., 2008

Collation

4p.

Language

English

ISBN/ISSN

0126-1312

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Edition

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Subject(s)

FEVER
ACETAINOPHEN

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