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On-admission Serum Soluble CD40 Ligand Level Predicts Subsequent Myocardial Damage in Acute Myocardial Infarction

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Background: Platelet activation plays an important role in plague rupture and thrombus formation. Activated platelets release CD40 ligand (sCD40L). It has coagulation and inflammation properties. Enhanced sCD40L activity has been found in acute mycocardial infarction, aspecially in ST-elevation myocardial infarction. The impact of this enhancement on the degree of myocardial damage remains uncertain, although avidence suggests association sCD40L level on-admission is predictive of subsequent myocardial damage following acute myocardial infarction. Methods: This study was a cross-sectional study. We consecutively enrolled patients with acute myocardial infarction admitted to ICCU Dr. Sardjito Hospital with onset < 24 hours. Blood collection for analysis of sCD40L was withdrawn on-admission before revascularization and heparinization. Serial measurement of creatine kinase (CK-MB) level in first 24 hours of admission was conducted, the highest level was considered, the highest level was sonsidered a peak level that reflacted myocardial damage. Troponin 1 was measured in single sample during 72 hours of admission. The association between serum sCD40L and peak CK-MB level was analyzed with Pearson correlation test. Statistical significancy was determined by p value < 0.05. Result: We enrolled 54 consecutive subjects, among them 37 subjects was STEM. There was a significantly positive correlation etween on-admission sCD40L and peak CK-MB level (r=0.320 ; p value = -.020). Nonetheless, sCD40L did not correlatewith troponin 1 level. In STEMI, this correlation was stronger (r = 0.424 ; p value = 0.010) and even more stronger in patients with TTEMI who underwent revascularization theapy (r=0.1515; p value = 0.029) Conclusion: On-admission serum sCD40L level is predictive of subsequent myocardial damage following acute myocardial infarction

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Ketersediaan

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Informasi Detail

Judul Seri

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No. Panggil

Berkala Ilmu Kedokteran, 40(4): 202-207

Penerbit

Surabaya : Fk. Universitas Gajah Mada., 2008

Deskripsi Fisik

4p.

Bahasa

English

ISBN/ISSN

0126-1312

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

myocardial infarction
PLATELET ACTIVATION

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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