The Effect of Chronic Ethanol Administration on Total Number of Pyramidal Cells In CA1 and CA3 of Hippocampus and Spatial Working Memory in Adolescent Rats (Rattus Norvegicus) | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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The Effect of Chronic Ethanol Administration on Total Number of Pyramidal Cells In CA1 and CA3 of Hippocampus and Spatial Working Memory in Adolescent Rats (Rattus Norvegicus)

Muh. Ihwan Narwanto - Personal Name; Soedjono Aswin - Personal Name; Mustofa - Personal Name;

Background: Adolescent brain may be more susceptible to damage by ethanol administration may cause morphological changes in the hippocampus, followed by deficit in the hippocampal function, including the impairment of memory. Objective: The aim of this study were to investigate the changes in the total number of pyramidal cells in CA1 and CA3 of hippocampus, and the relationship between these changes with spatial working memory of rats after chronic ethanol administration at adolescent age. Methods: Twenty five adolescent (30 days of age) male rats (Rattus norvegicus) were classified randomly into 5 groups, that is, namely control without treatment (C1), control with treatment (C2), treatment 1 (T1), treatment 2 (T2), and treatment 3 (T3) groups. Each group consisted of 5 rats. C2 group was given physiological saline, while T1, T2, and T3 groups were given ethanol at various doses of 1,2, and 3 g/kgBW/day, repectively, for 30 days by intraperitoneal injection. After chronic ethanol administration, the spatial working memory of 5 groups were tested using 8 arms radial maze for 12 days. At the end of the experiment, the rats were secrified and the brains were taken out for histological examination, by paraffin method and Cresyl violet staining. Result: Chronic ethanol administration on adolescent rats caused a decrease in spatial working memory (especially in group T3) (p

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Series Title: -
Call Number: Berkala Ilmu Kedokteran, 40(4): 172-180
Publisher: Surabaya : Puslitbang Farmasi, Badan Litbang Kesehatan., 2008
Collation: 5P.
Language: English
ISBN/ISSN: 0126-1312
Classification: -
Content Type: -
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Carrier Type: -
Edition: -
Subject(s): ETHANOL
ADOLESCENT
PYRAMIDAL CELLS
Specific Detail Info: -
Statement of Responsibility: -

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