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Effect of Homocysteine antiooxidants on Peroxidation Lipid of Essential Hypertension in Central Java, Indonesia

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Background: The increase in the homocysteine levl is related to the heightening of blood pressure and hypertension risk. Hyperhomocysteinemia encourages the production of free radical which can oxidize lipid. Lipid peroxidation can be prevented by several antioxidant such as vitamin C and E. Objective: This study is aimed at finding out the nature of the interaction effect between homocysteine and antioxidant vitamin on malondialdehyde level in essential hypertension. Method: This study was a case was a case-control nested to “Surveillance of Non-Communicable Diseases” in Purworejo Central Java. The subjects were men, assential hypertension and 20-60 years old that have normal value of urine creatinine, blood glucose, cholesterol and triacylglycerol. They have been take atihypertension drugs. The blood glucose, cholesterol, triaclglycerol, urine creatinine, vitamin C and malondialdehyde (MDA) levels were measured by spectrophotometer. Whereas the total plasma homocysteine and vitamin E were determined by HPLC. Result: The homocysteine level in the cases was higher than that of control and was significantly different (p=0,027). There was not significantly different of the vitamin C, vitamin e, and MDA between the cases and the control (p=0.538, p=0.390, and p=0.536) respectively. The MDA was positively correlated with hemocysteine (p=0.000) and negatively correlated with vitamin E (p=0.029), but it was not negatively significant correlated with vitamin C (p=0.067). The correlation had r=0.417; R²=0.174 and F=7.713. Conclusion: The high homocysteine level is one of hypertension risk factors and its effect through oxidative stress. The effect can be prevented by antioxidant vitamins, specially vitamin E.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Berkala Ilmu Kedokteran, 40(4): 105171

Penerbit

Yogyakarta : Fk. Universitas Gajah Mada., 2008

Deskripsi Fisik

4p.

Bahasa

English

ISBN/ISSN

0126-1312

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

antioxidants
hypertension
HOMOCYSTEIN

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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