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Peran Respons Imun pada Toksoplasmosis (The role of Immune Response to Toxoplasmosis)

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Toxoplasma gondii known as an opportunistic parasite, is commonly found in humans, and many species of mammals and bird. As an intracellular protozoa, this parasite can apparently penetrate and proliferate in virtually every cell in the body rapily multiplying as tachyzoites. During the earliest stage of infection. Toxoplasma triggers several components of innate immune system such macrophage, NK cells, dendritic cells and neutophiles responded by releasing cytokines such as IL-12, INFá and INFã. The innate immune responses exert a strong influence on developing T cell immunity. Toxoplasma gondii also potensially drives an extremely Th 1 response. The cellular immune response plays an active role in driving encysment of parasite. The cysts filled bradyzoit remains viable for long period and may exist mainly in the brain. Humoral antibodies play secondary role in contributing to protective immunity. An intact immune system is necessary for protection against Toxoplasma. The classic approach to the diagnosis of toxoplasma has always been based on the detection of immunoglobulin, especially IgM although in the early stage of infection IgA and IgE also can be detected. In this paper, the role of either specific immune response to Toxoplasma gondii as as wll as the elaborated in detail.

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Ebers Papyrus, 14(1) : 19-25

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Jakarta : FK. Universitas Tarumanegara., 2008

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4p.

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0854-8862

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