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Vasico-Ureteral Reflux and Reflux Nephropathy in Children with Recurrent Urinary Tract Infection

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We reviewed clinical and laboratory findings of patients with recurrent urinary tract infections (UTI) to detect the presence of vesico-ureteral reflux (VUR) or reflux nephropathy (RN). Only patients with evidence of more than 12 bouts of UTTs treated at the Department of Child Health, Cipto Mangunkusumo Hospital During the period from October 1, 1992 to September 30, 1993 were studed. There were 30 patients (15 boys, 15 girls) ranging in age from 2 months to 16 years (mean age = 5.5 years). RN as detected on dimercaptosuccinic acid (DMSA) scanning was found in 21 patients (12 unilateral, 9 bilateral). Mictiocyctourography (MCU) was done in 22 patients, revealing VUR in 14 patients, 10 of them showed renal scarring on DMSA scanning. Most of the patients has the duration of illness of less than 2 years. Clinical symptoms and signs (ypertension, proteinuria, increased plasma urea/creatinine) alone or in combination were more commoly found in patients with RN than in those without RN. The high prevalence of VUR and RN in patients with recurrent UTI in our series (63 percent and 70 percent, respectively), should draw our attention to detect UTI in its earliest stage, to be able to treat the patient promptly in order to prevent RN which eventually progresses into renal failure.

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Paediatrica Indonesiana,36(11-12)1996:239-247

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: ., 1996

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urinary tract infections

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