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The Comparison of the Use of Cycloproveria and HRP102 with Depomedroxy Progesterone Acetate (Perbandingan Pemakaian Sikloprovera dan HRP 102 sebagai Kontrasepsi Suntikan Bulanan dengan DMPA, Sebuah Kontrasepsi Suntikan Tiga Bulan : Sebuah Studi Pendahuluan)

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Objective: To compare the use of cycloprovera and HRP 102 (exposed group) with depomedroxy progesterone acetate (as control) in terms of bleeding pattern, continuation rate and body weight changes. Design/Data identification: Rondomized clinical trial. Material and method: Healthy women, 18-35 years of age, having at least one child, showed normal period during the last three months, did not taking any hormonal contraception before or has been passing the wash out period were recruited into the study, while lactating mother was excluded. Injection was given between day one to day five of their menstrual day, and repeated every four weeks for the exposed group and 12 weeks for the control. There were 93 cases each consisted of 31. Follow up was done every three months until the end of the first year. The study interes is were menstrual changes, number of discontinued women and changes of body weight. Results: The three groups were comparable in terms of age, parity, body weight, education, occupation and blood pressure. None from the cycloprovera and HRP 102 groups discontinued until the end of the study, while the comulative number of drop out cases from DMPA group was 29 percent consisting of 7.5 percent, 18.4 percent and 29 percent, for 3, 6, 9 and 12 months respectively. The number of subjects undergoing bleeding changes during one year study were 4.8 percent for cycloprovera, 0.8 percent for HRP 102 and 77.7 percent for DMPA. The most oredominant bleeding changes was amenorhea (40.3 percent for DMPA but none for both cycloprovera and HRP 102), followed by spoting (24.3 percent for cycloprovera and 23.4 perceent for HRP 102 and 14 percent for DMPA), and menorrhagia (26.2 percent for DMPA 0.8 percent for cycloprovera and 4 percent for HRP 102). In general the proportion of subjects undergoing spoting and menorrhagia declined as they continued using, but on the contrary the number of amenorrheic women were getting higher. All groups showed relatively small body weight gain i.e 1.0 kg, 0.7 kg and 1.3 kg for cycloprovera, HRP and DMPA respectively. Conclusions: Bleeding pattern in cycloprovera and HRP 102 users were more regular than in DMPA users that none of them discontinued spotting was fund more common in cycloprovera and HRP 102 users, but neither clinically nor statistically was significant.

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Majalah Obstetri dan Ginekologi Indonesia,20(3)199

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: ., 1996

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contraception

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