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Histological Changes in the Liver of Mice (Mus musculus L) Fed with Wild Tamarind, Leucaena leucocephala (Lam.) de Wit, Leaf Extract [Perubahan Histologi Organ Hati Mencit (Mus muscullus L.) yang Dicekok Ekstrak Daun Lamtoro, Leucaena leucocephala (Lam) de Wit H]

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A study of the effect of wild tamarind (Leucaena leucocephala) leafs extract on clinical symptoms and histological changes in liver of mice (Mus musculus) was conducting in the laboratory. Each of four equal groups of mice was individually fed with an artificial diet, impregnated with the leaf extract, at doses of 0 percent (control), 20 percent, 40 percent and 60 percent w/w on daily basis. Daily observations showed no evidence of clinical symptoms was finding on the control and treated mice. All mice gained almost similar body weight troughout the study. Microscopic examinations of liver tissues were observing after 36 days of treatment. There was no histological differences between control and mice treated with 20 percent of leaf extract. A slight damage in liver tissues was observing on mice treated with 40 percent of the extract. The damage increased when they were treating with 60 percent of leaf extract. Dilation of central and portal veins, fat occumulation, picnosis, followed by an inflammation of the portal vein area were observing in liver tissues of mice treated with the latter dose. It was clearly show that the level of liver damage increased with the increase of the dose. It was clearly show that the level of liver damage increase with the increase of the dose of wild tamarind leaf extract given.

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Majalah Kedokteran Indonesia,46(9)1996:477-483

Publisher

: ., 1996

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plants, extract

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