The Chloroquine Effect to the Lymphocyte Proliferation of BALB/C Mice Spleen, Infected by Lysteria Monocytogenes (Pengaruh Klorokuin terhadap Respons Proliferasi Limfosit dalam Limpa dari Mencit yang Disuntik Listeria Monositogenes) | Perpustakaan dan Galeri Kebijakan Kesehatan

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The Chloroquine Effect to the Lymphocyte Proliferation of BALB/C Mice Spleen, Infected by Lysteria Monocytogenes (Pengaruh Klorokuin terhadap Respons Proliferasi Limfosit dalam Limpa dari Mencit yang Disuntik Listeria Monositogenes)

et al - Nama Orang; Pudjadi - Nama Orang;

A study on choroquine effect to the lymphocyte proliferation of BALB/c mice spleen, infected by Lysteria monocytogenes was carried out. Chloroquine, used for curing malaria and rheumatoid arthritis, is known suppressed the imune response. In this study, 70 BALB/c male mice were divided in 3 groups. The first and the second groups consist of 3 subgroups, which each subgroup consisted of 10 mice. Group I was injected with Listeria monocytogenes, while group II had been treated with chloroquine prior to Listeria injection. The thirth group is used as the control. At the forth day after injection, one subgroup of each treated group were killed for counting the total lymphocyte from spleen. The same procedure was also done for the other subgroups at the fifth and the sixth day. The total number of lymphocyte and the number of lymphoblast increased significantly (p less than 0.05) at the forth, fifth and sixth days Listeria injection, while the total number of lumphocyte and the number of lymphoblast decreased significantly (p less than 0.05) in chloroquine treated mice group. It is concluded that live Listeria monocytogenes stimulate lymphocyte proliferation but chloroquine given before live listeria monocytogenes immunization decrease lymphocyte proliferation in the spleen. It is suggested to measure the immune status before chloroquine therapy for malaria and rheumatoid arthritis in human and monitor during the chloroquine treatment.

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Judul Seri: -
No. Panggil: Majalah Kedokteran Diponegoro,31(1 2)1996:51-58
Penerbit: : ., 1996
Deskripsi Fisik: -
Bahasa
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Subjek: chloroquine
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