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Randomize Double Blind Clinical Trial of Loratadine and Astemizole on the Therapy of Perennial Rhinitis Allergic (Uji Klinik Secara Acak Buta Ganda Loratadine dan Astemizole pada Pengobatan Rinitis Alergi Perenial)

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Objectives to evaluate the efficacy and the adverse effects of Loradine and Astemizole once daily dose for 14 days treatment, especially to see whether Loratadine is faster than Astemizole in terms of relieving perennial allergic rhinitis symptoms. Study design: Rondomized, double blind clinical trial. Methodology: 65 perennial allergic rhinitis who fulfilled the eligibility criteria were rondomized allocated into two groups of treatment, Loratadine and Astemizole for 14 days. The result of the treatment was evaluated by subjective patient assessment using 4 point rating scale. Sedation and other adverse effects were evaluated by subjective patient assessment by reporting unusual sensation during taking the drugs. Result: loratadine is better than Astemizole in terms of relieving perennial allergic rhinitis symptom during 14 days treatment. Significance difference, however, was found at the first day of treatment only. There was no significance difference of adverse effects during 14 days treatment. Implication: Four patients who need antihistamines and they require high concentration in their daily activity, Loratadine and Astemizole can be prescribed. However for patients who require symptom relief faster, Loratadine is more appropriate.

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Majalah Kedokteran Diponegoro,31(1 2)1996:13-21

Publisher

: ., 1996

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Subject(s)

astemizole
rhinitis, allergic, perennial

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