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During the progression stage, malignant tumors showed heterogenecity with some cells showing invasive and metastatic capabilities. Bone metastasis is usually hematogenic and predominantly in red bone marrow. This is supported by retrograde vein flow (Botson's plexus), micro-anatomy of the vascularized channels in red bone marrow in sinusoid system, high blood flow and higher concentration of cy…
A toxicity test was performed on separately 11 extracts of Indonesian medicinal plant (Elaeocarpus gramiflorus J.E. Smith, Vitex negundo L., Leucaena leucocephala (Lmk) de Witt, Borreria articularis (L.f) F.N. Will, Ardissia humilis vahl., Achyranthus bidentata L., Hyptis capitata Jack., Gynura procumbens (Lour.) Merr., Annona squamosa L., Annona murricata L. and Artemisia vulgaris L.,) by 'Bri…
The present work was aimed to compare the pharmacokinetic profiles of sulfanilamide and its derivative sulfamethizole in the rat. Female Wistar rats were divided into two equal groups randomly, and each was injected with sulfanilamide or sulfamethizole (40 mg/kg: ip). The sulfonamide blood concentrations were monitored colorimetrically employing a Bratton-Marshall assay method. The result showe…
The possibility of using a conventional coating-pan by modifying its interior part to prepare film coated tablet has been studied. The aim of the study is to use the conventional coating pan for preparing film coated tablet faster. Pharmacoat-606 was used as film coating after being solubilized in ethanol. Film coating was done by spreading the pharmacoat-606 solution using both conventional an…
Malaria is still a major public health problem in Indonesia, and prevalence rate is high in some areas. To control malaria is extremely difficult due to interaction between host-agent and vector. Malaria falciparum parasites have been resistant to chloroquine due to the long and improver use. The alternative drugs such as fansidar and quinine are more toxic and often produce a severe side effec…
Fat is not only as an important component of food but also widely used in pharmaceutical preparations. The presence of lard in foods, however, creates a big problem among Moslem consumers. The study was aimed to obtain an analytical method to distinguish lard from other animal fats. Fat was extracted from a blended meat (chicken, cow, goat, pork) with hexane in a soxhlet for 6 hours. The extrac…