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In view of demographic trends, andrology will increasingly be concerned with problems of the aging male, especially with aspects of fertility. While there is considerable interindividual variation, fertility in men usually persists well into old age. However, increased occurence of spontaneous mutations means a higher genetic risk for children of older fathers. Diminished androgen levels in old…
Even though many efforts have been done for fifteen years since the birth of the world's first test tube baby, the rate of assisted reproductive delivery was still low. Nowadays, tubal replacement procedure becomes more popular than the uterine transfer. However, this technique still ends up with a very high incidence of abortion. Many workers claimed that coculture system resulted in more prom…
Chloroquine resistant malaria is a serious problem in Indonesia especially in Irian Jaya. Artemether is a new antimalarial drug, reported to be very effective and safe in clinical studies. This drug is not yet available in Indonesia. To obtain an alternative antimalarial drug for the treatment of chloroquine resistant falciparum malaria cases, a trial of artemether treatment for uncomplicated f…
This retrospective study aimed to review the clinical features and management of patients with secundum atrial septal defect (ASD 2 degree). The subjects studied were 90 boys (39.8 percent) and 136 girls (60.2 percent), treated at the Outpatient Clinic, Cardiology Division, Department of Child Health, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, from January 1, 1983 to December 31, 1992. Cl…
Lysozyme has an ability to degrade some substrates of carbohydrate derivative, lipid and protein, it might also capable to degrade membrane cell of bacteria as well as antibiotics. Therefore the influence of lysozyme toward antibiotic activity had been investigated. The experiments performed using 7-Amino Cephalosporanic Acid (7-ACA) group, (sephalexin and sephradin) and 6-Amino Penicillanic Ac…
The aim of this research is to obtaine a sustained release dosage form with cellulose derivatives by microencapsulation method. In this study, the microencapsulation method modified from Lordi, by spraying the ethanolic solution of methylcellulose, ethylcellulose and hydroxyprapyl methylcellulose. Particles of the active substance were put in the coating pan and sprayed carefully with the solut…
Anthistamines such as CTM, diphenhydramine HCI, promethazine HCI and astemizol have different physicochemical properties due to the differences in their chemical structures. These physicochemical properties would affect their transport behavior through cellophane membrane. This study would like to investigate the effect of physicochemical properties of the antihistamines on their transport thro…
The effectiveness of sun screen depends on the stability of drug used as an active compound, and its influence on the chemical components in skin cell. To study of the effectiveness of octylmethoxycinamate (OMC) as sun screen, the phostostability of OMC was examined by exposing the compound with direct sunlight. The influence of OMC on the stability of tryptophan was also studied. The layer was…