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Background: Exercise increases the need for oxygen to generateATP through oxidative phosphorylation. If the high energy demand during exercise is not balanced by sufficient oxygen supply, hypoxia occurs in skeletal muscle tissue leading to upregulation ofhypoxia inducible factor-1α (RIF-1α). The activity of RIF-1α increases the expression ofvarious genes in order to reduce the metabolic depe…
Centella asiatica L. (CA) and chitosan are natural products that promote fibroblast pro-liferation in wound healing. In this study, ethanolic CA extract and aqueous CA extract are encapsulated in chitosan nanoparticies (CNP) by ionotropic gelation. The skin's cell renewal rate decreases along with the natural process of aging.The aim of this study is to com pare the regenerating capability of t…
The Objective of this work was to formulate and evaluate captopril gel to assess its suitability for transdermal delivery by passive and iontophoresis. A polymer gel was prepared using hydroxypropyl methyl cellulose and in vitro skin permeability was assessed in full thickness skin of rabbits and pigs. For in vivo studies New Zealand rabbits were used. In vitro passive permeation was carried ou…
Stability of erythropoietin (EPO) depends on its glycosylation states. With more glycosylation sites, the EPO protein will be more stable and also increase its half-life. A construct of recombinant human erythropoietin (rhEPO) which contains 2 additional N-link for glycosylation were designed. Based on translation analysis using ORF (open reading frame)-finder and protein alignment analysis usi…
Ribosome Inactivating Proteins (RIPs) are compounds isolated from plants with ability to inhibit protein synthesis. The inhibition of protein synthesis is due to inactivation of ribosomal RNA through a site-specific deadenylation mediated by RNA N -g lycosid a se . Reportedly, RIPs mainly possess wide range of bioactivity including antiviral activity against plant infections. Other activities o…
Quality assurance of malaria microscopy is an important issue in health service and health research for a better case management. In monitoring Dyhydroartemisinin-Piperaquine, quality assurance was a part of this research activities at sentinel sites in Kalimantan and Sulawesi. This activity was carried out to confirmed diagnosis of malaria cases that could be analysed, and to evaluate the skil…
Dengue hemorrhagic fever (DHF) happens to be a public health problem in Samarinda city, East Kalimantan Province. Dengue was reported endemic in the entire six subdistricts of the city. Various vector control programs have been conducted by the Health Office, yet the dengue cases were still occurred on the previous years. Comprehensive research was conducted to determine the spatial distributio…
Satyrium nepalense is an endangered medicinal herb found at the higher altitude of 2400-5000m. Local inhabitant used tubers of Satyrium nepalense as an energetic tonic and as an important medicine to cure different type of fever in traditional health care system of Uttarakhand (INDIA). Present study was carried out to evaluate the phytochemical, antibacterial screening against four (Streptococc…
Welding fumes caused the decreasing of forced vital capacity (FVC). The study aimed to identify several factors related to FVC. The subject of this cross-sectional study consisted of welders in an automobile manufacture outskirt of Jakarta in 2012. We used purposive sampling selection. The assessments of FVC were using spirometri. Exposure fumes value of the workplace based on the assessemen…
Background:Several coping strategies may minimize stress levels. This study aimed to identify several dominant coping strategies related to total stress score levels. Methods:A cross-sectional purposive sampling method study among postgraduate medical students of the Faculty of Medicine, Universitas Indonesia was done April-July 2011. We used a coping strategies questionnaire and the WHO SRQ…