Captopril is a selective- Inhibitor of angiotensin-convertinq enzyme (ACE) and is formulaned by, several pharmaceuical companies: irr Lndonesia. This stwdy was corrducted to compare tlhe bioavailability of captopril' tablet with reference preducts in healthy volunteers. The relative bioavailability of captopril was deterrnined in single dase, randomized, crcssover, and two-phase studies. The re…
Non Steroid Anti-Inflammatory (NSAID) is one type of Anti-Inflammatory drug that is used to treat pain in patients of osteoarthritis (OA) and rheumatoid arthritis (RA). The use of NSAIDs can cause gastrointestinal side effects. To prevent the side effects, NSAIDs are prescribed in combination with gastroprotective agent (GPA). The aim of the study is to determine the factors considered in the G…
Econazole is an azole antifungal agent which can block the calcium release-activated calcium (CRAC) current in human leukaemic T cell line. The phenomenon is also possible to occur in mast cell such as RBL-2H3 (rat basophilic leukemia) cells, a tumor analog of mast into the cells, a tumor analog of mast cells. In the study, we investigated effect of econazole on 45 Ca 2+ uptake into the cells…
Long term goal of this study is the use of combrang (Nicolaia speciosa Horan) as an ingredient of traditional medicine after after being evaluated through predicinal testing and clinical trials both extract and its bioactive compounds. This study includes analgesic-antiinflammatory activity test of n-hexane, chloroform, ethyl acetate and methanol extract of combrang stem. Analgesic test againt…
Tetrahydropentagamavunon-O (THPGV-O) is assumed to be main metabolite product of biotransformation process of PGV-O. THPGV-O was synthesized by converting PGV-O to the compound by hydrogenation with PdjC as a catalyst. PGV-O potently inhibited the histamine release from ~at mast cells in vitro and in vivo, however, ironically only traces amount of compound was found in the blood. THPGV-O is ass…
Asthma is a chronic inflammatory airway disease involving reversible airway constriction and airway hyperresponsiveness (AHR) to allergens, airway edema, and increased mucus secretion turner cells. To date, exploration of antiasthmatic drug is still being studied both from natural products or sinthetic processes. One of the sinthetic compound is pentagamavunon-O (PGV-O) which possesses anti-inf…