ABSTRACT CD4.1L-4+ cells play a role in asthmatic inflammation. The role of pro inflammatory CD8+in asthma is associated with Tc2 subset that produces IL-4+ Immunotherapy is a useful asthma treatment and immunomodulatory is considered to improve its effectiveness. So far, there has been no study evaluating the long-term administration of immunotherapy, probiotics, and Nigella sativo on the m…