Ultraviolet A (UVA)irradiation on human skin can generate free radical and stimulate matrix metalloproteinase produktion resultingin collagen degradation and transforming growth factor beta (TGF-β) inhibition. It causes synthesis collagen inhibition and induces cell death. Α-Lipoic acid (ALA) is an universal antioxidant and a powerful scavenger of free radicals. In this study we investigated …