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Correlation of hypoxia inducible factor-la and vascular endothelium growth fa…
Background: Exercise increases the need for oxygen to generateATP through oxidative phosphorylation. If the high energy demand during exercise is not balanced by sufficient oxygen supply, hypoxia occurs in skeletal muscle tissue leading to upregulation ofhypoxia inducible factor-1α (RIF-1α). The activity of RIF-1α increases the expression ofvarious genes in order to reduce the metabolic depe…
- Edition
- -
- ISBN/ISSN
- 2252-8083
- Collation
- 8p
- Series Title
- -
- Call Number
- Medical Journal Indonesia, 21 (3) 2012 : 133-140
Expression of manganese superoxide dismutase in rat blood, heart and brain du…
Background: Hypoxia results in an increased generation of ROS. Until now, little is known about the role of MnSOD - a major endogenous antioxidant enzyme - on the cell adaptation response against hypoxia. The aim of this study was to determine the MnSOD mRNA expression and levels of specific activity in blood, heart and brain of rats during induced systemic hypoxia. Methods: Twenty-five mal…
- Edition
- -
- ISBN/ISSN
- 0853-1773
- Collation
- 6p.
- Series Title
- -
- Call Number
- Medical Journal of Indonesia:20(1)2011:27-33
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