Piper retrofractum L is a plant that acts as a stimulant on the body. A preliminary study showed that administration of infusion of 2.1 mg/10 g body weight had androgenic and anabolic effects in white mice. Piperine is the main alkaloid suspected to have an aphrodisiac effect. Centella asiatica and Curcuma domestica are the excipients. The objective of this research was to determine the toxicit…