One of the means to prepare a controlled release dosage from is by using cellulose derivatives matrix. In this study paracetamol and ethylcellulose were used as a model compound and matrix substance, respectively. Paracetamol release was performed in a buffer phosphate medium pH 7.0 and the temperature was kept constant at 37 degree C. Results showed that paracetamol relase from ethylcellulose …
Viscosity of ointment base may be altered by addition of viscous substances. The viscosity alteration pattern of the viscousity of the vaseline ointment base due to addition of various amount of propylene glycol has been studied, and the viscousity of vaseline ointment base containing various propylene glycol concentration have been determined by using Brookfield VT 04 viscometer. Results showe…
Controlled release dosage form is a dosage form with releases its contents in a controlled manner. Hydroxypropyl methylcellulose (HPMC) is a cellulose derivative which could from gel and substance may be used as matrix for a controlled release matrix dosage form. In this study, theophylline was used since this drug is suitable for controlled release dosage form and HPMC used was HPMC high visco…
Anthistamines such as CTM, diphenhydramine HCI, promethazine HCI and astemizol have different physicochemical properties due to the differences in their chemical structures. These physicochemical properties would affect their transport behavior through cellophane membrane. This study would like to investigate the effect of physicochemical properties of the antihistamines on their transport thro…
One of the means to prepare a controlled release dosage from is by using cellulose derivatives matrix. In this study paracetamol and ethylcellulose were used as a model compound and matrix substance, respectively. Paracetamol release was performed in a buffer phosphate medium pH 7.0 and the temperature was kept constant at 37 degree C. Results showed that paracetamol relase from ethylcellulose …
Viscosity of ointment base may be altered by addition of viscous substances. The viscosity alteration pattern of the viscousity of the vaseline ointment base due to addition of various amount of propylene glycol has been studied, and the viscousity of vaseline ointment base containing various propylene glycol concentration have been determined by using Brookfield VT 04 viscometer. Results showe…
Controlled release dosage form is a dosage form with releases its contents in a controlled manner. Hydroxypropyl methylcellulose (HPMC) is a cellulose derivative which could from gel and substance may be used as matrix for a controlled release matrix dosage form. In this study, theophylline was used since this drug is suitable for controlled release dosage form and HPMC used was HPMC high visco…
Anthistamines such as CTM, diphenhydramine HCI, promethazine HCI and astemizol have different physicochemical properties due to the differences in their chemical structures. These physicochemical properties would affect their transport behavior through cellophane membrane. This study would like to investigate the effect of physicochemical properties of the antihistamines on their transport thro…