Aim This study aimed to elicit the protective effect of Sargassum echinocarpum extract on endothelial dysfunction in thoracic aorta of streptozotocin-induced diabetic rats. Methods The animals were divided into 5 groups. The first was normal, the second was diabetic non treated animals. The third to fifth groups were the diabetic animals which given Sorgassum echinocarpum extract (150; 300, an…
Macro and micro vascular diseases are currently the principal causes of morbidity and mortality in diabetes mellitus patients. Loss of the modulatory role of the endothelium may be a critical and in'itiating factor in the development of diabetic vascular disease. Polyphenol is known behave protective active compound to function endothelium cell. Polyphenol that contained in brown algae was phlo…
Isoflavon as the active compound in soybean can improve of antioxidant status. Zn is needed to stimulate antioxidant enzymes activities, while vitamin E acts as chain breaking antioxidant that prevent chain reaction of free radicals. Material that use in this research were isoflavone rich-soybean flour (TKI), zinc sulfate (ZnS04•7H,O), and vitamin E (α-tokoferol asetat), while the data were …