ABSTRACT Rheumatoid arthritis is an autoimmune disease which is initiated by T-cell dependent antigen activation that lead to nu immune response type. Tumor necrosis factor is the central cytokine in the AR pathogenesis. This research aimed to investigate the correlation between vitamin D, TNF-α and the clinical severity of rheumatoid arthritis. A cross sectional design was performed…
Although improvements have been made in the therapeutic management of the last two decades, but the prognosis of lupus nephritis remains unsatisfactory. It is therefore necessary to idenitfy a biomarker of disease activity. This study was aimed to measure the role ofTGF-61 and IFN-γ urine as biomarker for chronicity index of lupus nephritis. An observational study was conducted over al-year us…
Airway remodeling is an important thingin asthma. The increase of airway smooth muscle massa is a prominent feature of asthmatic airway remodeling. The importance role of airway amooth muscle cell (ASM) apoptosis in airway remodeling is unknown. T cell also had important role in asthma, wheas CD4 T cellrole in airway remodeling has already, but how CD8 T cell role in airway remodeling is still…
Antiphospholipid syndrome (APS) is a disorder of recurrent vascular thrombosis, pregnancy losses and thrombocytopenia associated with persistently elevated levels of antiphospholipid antibodies (APA). Many patients with APS have clinical and laboratory features found in other autoimmune diseases, particulary SLE. Such patients should be defined as having a 'secondary' APS to distinguish them fr…
Antiphospholipid syndrome (APS) is a disorder of recurrent vascular thrombosis, pregnancy losses and thrombocytopenia associated with persistently elevated levels of antiphospholipid antibodies (APA). Many patients with APS have clinical and laboratory features found in other autoimmune diseases, particulary SLE. Such patients should be defined as having a 'secondary' APS to distinguish them fr…
The aim of the study was to assess the clinical manifestations and survival rate in SLE patients in Malang. Sixty eight SLE patients hospitalized in dr Saiful Anwar General Hospital in 1985-1994 were studied retrospectively. All the patients fulfilled the revised ARA criteria. The results showed that the frequency of lupus manifestation were arthritis 92.7 percent, oral ulceration 86.8 percent,…
The aim of the study was to assess the profile of antiphospholipid antibodies (AP) in patients with recurrent spontaneous abortion (RSA). Fifty pregnant women with RSA were studied compared with 52 healthy pregnant women as control. The results showed that the frequency of APA were significantly higher in pregnant women as control. The results showed that the frequency of APA were significantly…