Background : Hyperuricaemia stimulated pro-inflammatory cytokines like TNF-a, IL-1 and IL-6They stimulate leucocyte adhesion to monosodium urate deposition area and multiply inflamatory response. Indonesian Bay-Ieaf (Eugenia polyantha), celery (Apium graveolens) and blackseed (Nigella sativa) had known decrease inflammatory response. These plants are common in lndonesia but had not clinically s…