ABSTRACT Post stroke depression (PSD) Is one of stroce complications with prevalence of 9-60%. Theories of pathophysiology involved: the hypothesis of Infarct location, infarct size vascular depression, biochemical neuronal factor such as hypothesis of neurotransmitter, immune dysfunction. ypothaiarilc-pltultary-adrenal axis activation and reurogenesis nypothesis. Diagnosis is based on DSM I…