Most of glucose solution (78%) in the lens through anaerobic glycolysis, 14% through the pentose phosphate, about 5% through the polyol. In condition sof hyperglycemia, saturated fast lane anaerobic glycolysis, and glucose will choose the path of polyol. In the polyol path glucose to sorbitol. In circumstanees where sorbitol is broken dowen into fructose by polyol dehydrogenase enzymes, but in …