Captopril is a selective- Inhibitor of angiotensin-convertinq enzyme (ACE) and is formulaned by, several pharmaceuical companies: irr Lndonesia. This stwdy was corrducted to compare tlhe bioavailability of captopril' tablet with reference preducts in healthy volunteers. The relative bioavailability of captopril was deterrnined in single dase, randomized, crcssover, and two-phase studies. The re…
Atenolol has a low oral bioavailability and a short elimination half-life. Therefore, alternative delivery system isimportant. Transdermal iotophoresis i.e. a systemic drug delivery via the skin, implementing a low intensity of electrical current, is one attractive candidate. This study evaluated feasibility of atenolol transdermal transport when lontophoresis was applied after enhancer pretrea…