Thyroid hormones are proven to have a direct effect on sexual development and reproductive function. Hypothyroidism in men cause decreased libido, impotence, and oligospermie. Thyroid disorders associated with abnormal testicular morphology and function. Selenium was closely related to male fertility. Glutathione peroxidase 4 (GPx4) was first known as the antioxidant enzymes is selenoenzyme whi…